X-linked dominant
X-linked dominant disorders result from pathogenic variants in genes that are located on the X chromosome. The disorder is considered ‘dominant’ because the presence of a pathogenic variant in only one copy of the gene is sufficient to cause the disorder. Males will usually exhibit more severe manifestations than females. Fathers can not pass on the disease to sons as they inherit the Y, not the X chromosome, also known as absence of ‘male-to-male’ transmission.
