BACKGROUND AND PURPOSE:

• Liao et al. (Gynecologic Oncology, 2023) determined the rate of uterine cancer among Hispanic women

METHODS:

• Retrospective cohort study
  • Data derived from the United States Cancer Statistics (USCS) database and the Behavioral Risk Factors Surveillance System (BRFSS) survey from 2001 to 2018
• Population
  • ≥18 years
• Diagnosed with uterine cancer in the Exposures
  • Age: Divided into 5 to 10 year age groups
  • Ethnicity: Hispanic women and non-Hispanic White women
• Study design
  • Reproductive age definition: <50 years
  • Young reproductive age: 18 to 40 years
  • Obesity-related cancers: Classified according to the CDC
  • The average annual percent change (AAPC) calculated using joinpoint regression
• Primary outcomes
  • Incidence rates of overall uterine cancers and obesity-related uterine cancers
  • AAPC of uterine cancers

RESULTS:

• 843,116 patients with uterine cancer
  • In reproductive age women: 12.7% of cases
• In 2018, Hispanic women aged 35 to 39 years had the highest incidence of uterine cancer among young reproductive-age women
  • Hispanic women: 13.9 per 100,000
  • Non-Hispanic White women: 9.3 per 100,000
• The incidence of new uterine cancers increased annually for women aged 25 to 39 in both groups with Hispanic women experiencing a higher AAPC
  • Hispanic women: AAPC 4.0 to 4.5%
  • Non-Hispanic White women: AAPC 1.5 to 2.3%
• Hispanic women aged 35 to 39 living in the West specifically had higher incidences of uterine cancer and AAPCs
  • Incidence
    • Hispanic women: 14.93 per 100,000
    • Non-Hispanic White women: 6.61 per 100,000
  • AAPCs
    • Hispanic women: 5.24%
    • Non-Hispanic White women: 1.48%
• By the year 2026, the incidence of uterine cancer in 35 to 39 year old Hispanic women in the West will be three times that of White women
  • Hispanic women: estimated 22.4 per 100,000
  • Non-Hispanic White women: estimated 7.4 per 100,000
• In the BRFSS survey, Hispanic women aged 35 to 44 years reported an obesity rate of 30.1% in 2018
  • The rate of obesity in Hispanic women rose by 1.4% annually from 2001 to 2018

CONCLUSION:

• The overall incidence of uterine cancer continues to grow for women in the US with Hispanic women experiencing particularly high increases in incidence each year
• The authors state

The incidence of uterine cancer is rising rapidly in young reproductive-age Hispanic women compared to White women

These results may have public health implications towards the prevention and early detection of uterine cancer in this high-risk population 

Learn More – Primary Sources:

The rising rates of uterine cancer in Hispanic women of reproductive age in the United States (444)